The White Water to Blue Water (WW2BW) Initiative was formulated in 2002 during the World Summit on Sustainable Development. WW2BW responds to the World Summit’s “Oceans” agenda with an integrated approach to sustainable use of water resources. In an effort to address water pollution and scarcity, United States government agencies, including the State Department, NOAA, USAID, as well as the United Nations, governments of the Wider Caribbean Region, and a number of non-governmental organizations have come together to plan and implement programs which will lead to the conservation and sustainable management of both freshwater and coastal marine resources in the Caribbean. WW2BW stimulates partnerships to promote integrated watershed and marine-based ecosystems management in support of sustainable development. Four thematic areas are supported: integrated watershed management, marine ecosystem-based management, sustainable tourism, and environmentally sound marine transportation. The outcome of the WW2BW partnership in the Wider Caribbean may serve as the blueprint for future programs on watershed and marine ecosystem-based management in Africa and the South Pacific.