A method of stabilizing enzymes by binding antibodies to them. The antibodies should not block the active site of the enzyme, as otherwise the protein is stabilized but is inactive as a catalyst. Monoclonal antibodies are usually used as they bind to specific bits of the protein surface. If the enzyme tries to unfold into an inactivate structure, it must not only overcome its own binding energy but also throw off all the bound antibodies; this requires more energy, and so is a correspondingly slower process.