1) A neoplasm that often involves blood vessels, usually occurs in the pancreas or the wall of the duodenum, and produces excessive amounts of gastrin which stimulates gastric-acid secretion and consequent formation of ulcers especially in the duodenum and the jejunum.

2) A tumor that causes overproduction of gastric acid. It usually begins in the duodenum (first part of the small intestine that connects to the stomach) or the islet cells of the pancreas. Rarely, it may also begin in other organs, including the stomach, liver, jejunum (the middle part of the small intestine), biliary tract (organs and ducts that make and store bile), mesentery, or heart. It is a type of neuroendocrine tumor, and it may metastasize (spread) to the liver and the lymph nodes.